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Effects of high magnetic fields on the diffusion of biologically active molecules

SYSNO ASEP	0556091
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Effects of high magnetic fields on the diffusion of biologically active molecules
Author(s)	Zablotskii, Vitalii (FZU-D)_ORCID Polyakova, Tetyana (FZU-D)_ORCID Dejneka, Alexandr (FZU-D)_{RID, ORCID}
Number of authors	3
Article number	81
Source Title	Cells. - : MDPI Roč. 11, č. 1 (2022)
Number of pages	13 s.
Language	eng - English
Country	CH - Switzerland
Keywords	magnetic field ; molecular diffusion ; drug diffusion ; hemoglobin ; red blood cells
Subject RIV	BO - Biophysics
OECD category	Particles and field physics
R&D Projects	EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	FZU-D - RVO:68378271
UT WOS	000741737300001
EID SCOPUS	85122298234
DOI	10.3390/cells11010081
Annotation	The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species including oxygen, hemoglobin, and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of an MF as well as reveal the underlying mechanism of the MF’s effect on diffusion. We found that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that an MF may significantly alter the gas exchange in an erythrocyte and cause swelling.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2023
Electronic address	http://hdl.handle.net/11104/0330472

Number of the records: 1