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Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production
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SYSNO ASEP 0555981 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production Author(s) Vokurka, M. (CZ)
Lacina, L. (CZ)
Brabek, J. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Ng, Y.Z. (SG)
Smetana Jr, K. (CZ)Number of authors 6 Article number 964 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 23, č. 2 (2022)Number of pages 22 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords cancer microenvironment ; cancer ecosystem ; cancer-associated fibroblast ; il-6 ; exosome Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects EF16_019/0000785 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-05048S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000748216800001 DOI 10.3390/ijms23020964 Annotation Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://www.mdpi.com/1422-0067/23/2/964
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