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Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)

SYSNO ASEP	0555852
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)
Author(s)	Malenínská, Kristýna (FGU-C)_{ORCID, RID} Janíková, Martina (FGU-C)_ORCID Radostová, Dominika (FGU-C)_{ORCID, RID, SAI} Vojtěchová, Iveta (FGU-C)_{ORCID, RID} Petrásek, Tomáš (FGU-C)_{RID, ORCID, SAI} Kirdajová, Denisa (UEM-P)_{RID, ORCID} Anděrová, Miroslava (UEM-P)_{RID, ORCID} Svoboda, Jan (FGU-C)_{RID, ORCID} Stuchlík, Aleš (FGU-C)_{RID, ORCID}
Article number	113678
Source Title	Behavioural Brain Research. - : Elsevier - ISSN 0166-4328 Roč. 419, 15 Feb (2022)
Number of pages	6 s.
Language	eng - English
Country	NL - Netherlands
Keywords	immunochallenge ; poly(I:C) ; maternal immune activation ; cognitive deficit ; schizophrenia ; behavioral tests ; mouse ; interneurons ; prenatal infection
OECD category	Neurosciences (including psychophysiology
R&D Projects	GA19-03016S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	FGU-C - RVO:67985823 ; UEM-P - RVO:68378041
UT WOS	000727768000003
EID SCOPUS	85120167543
DOI	10.1016/j.bbr.2021.113678
Annotation	Maternal immune activation has been identified as a significant risk factor for schizophrenia. Using rodent models, past work has demonstrated various behavioral and brain impairments in offspring after immune-activating events. We applied 5 mg/kg of poly(I:C) on gestation day 9 to pregnant mouse dams, whose offspring were then stressed during puberty. We show impairments in attentional set-shifting in a T-maze, and a decreased number of parvalbumin-positive interneurons in the hippocampus as a result of peripubertal stress specifically in females.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2023
Electronic address	https://doi.org/10.1016/j.bbr.2021.113678

Number of the records: 1