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INFRAFRONTIER quality principles in systemic phenotyping
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SYSNO ASEP 0554550 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title INFRAFRONTIER quality principles in systemic phenotyping Author(s) Ehlich, H. (DE)
Cater, H. (GB)
Flenniken, A.M. (CA)
Goncalves Da Cruz, I. (FR)
Mura, A. (FR)
Ntafis, V. (GR)
Raess, M. (DE)
Selloum, M. (FR)
Stoeger, C. (DE)
Suchanová, Šárka (UMG-J)
Vuolteenaho, R. (FI)
Brown s, S.D.M. (GB)
Herault, Y. (FR)
Hinttala, R. (FI)
Hrabe de Angelis, M. (DE)
Kollias, G. (GR)
Kontoyiannis, D.L. (GR)
Malissen, B. (FR)
McKerlie, C. (CA)
Sedláček, Radislav (UMG-J) RID
Wells, S. (GB)
Zarubica, A. (FR)
Rozman, Jan (UMG-J)
Sorg, T. (FR)Number of authors 24 Source Title Mammalian Genome. - : Springer - ISSN 0938-8990
Roč. 33, č. 1 (2022), s. 120-122Number of pages 3 s. Publication form Online - E Language eng - English Country US - United States Keywords quality control ; phenotyping ; animal model ; reproducibility ; replicability ; ethics Subject RIV EB - Genetics ; Molecular Biology OECD category Genetics and heredity (medical genetics to be 3) R&D Projects LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure CCP II - 90126 - Ústav molekulární genetiky AV ČR, v. v. i. Method of publishing Limited access Institutional support UMG-J - RVO:68378050 UT WOS 000679610900001 DOI 10.1007/s00335-021-09892-2 Annotation Improving reproducibility and replicability in preclinical research is a widely discussed and pertinent topic, especially regarding ethical responsibility in animal research. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving, and distribution of model mammalian genomes, is addressing this issue by developing internal quality principles for its different service areas, that provides a quality framework for its operational activities. This article introduces the INFRAFRONTIER Quality Principles in Systemic Phenotyping of genetically altered mouse models. A total of 11 key principles are included, ranging from general requirements for compliance with guidelines on animal testing, to the need for well-trained personnel and more specific standards such as the exchange of reference lines. Recently established requirements such as the provision of FAIR (Findable, Accessible, Interoperable, Reusable) data are also addressed. For each quality principle, we have outlined the specific context, requirements, further recommendations, and key references. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://link.springer.com/article/10.1007/s00335-021-09892-2
Number of the records: 1