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Diverse telomeres in trypanosomatids
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SYSNO ASEP 0554492 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Diverse telomeres in trypanosomatids Author(s) Polakova, E. (CZ)
Záhonová, Kristýna (BC-A) ORCID
Albanaz, A.T.S. (CZ)
Butenko, Anzhelika (BC-A) RID, ORCID
Lukeš, Julius (BC-A) RID, ORCID
Yurchenko, V. (CZ)Number of authors 6 Source Title Parasitology. - : Cambridge University Press - ISSN 0031-1820
Roč. 148, č. 10 (2021), s. 1254-1270Number of pages 17 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords dna-base-j ; genomic organization ; length regulation ; leishmania-major ; parasite ; evolution ; brucei ; protein ; maintenance ; polymerase ; Genomes ; telomere maintenance ; Trypanosomatidae Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA18-15962S GA ČR - Czech Science Foundation (CSF) GA20-07186S GA ČR - Czech Science Foundation (CSF) EF16_019/0000759 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BC-A - RVO:60077344 UT WOS 000674635600015 EID SCOPUS 85102705137 DOI 10.1017/S0031182021000378 Annotation Telomeres are the ends of linear eukaryotic chromosomes facilitating the resolution of the 'end replication and protection' problems, associated with linearity. At the nucleotide level, telomeres typically represent stretches of tandemly arranged telomeric repeats, which vary in length and sequence among different groups of organisms. Recently, a composition of the telomere-associated protein complex has been scrutinized in Trypanosoma brucei. In this work, we subjected proteins from that list to a more detailed bioinformatic analysis and delineated a core set of 20 conserved proteins putatively associated with telomeres in trypanosomatids. Out of these, two proteins (Ku70 and Ku80) are conspicuously missing in representatives of the genus Blastocrithidia, yet telomeres in these species do not appear to be affected. In this work, based on the analysis of a large set of trypanosomatids widely different in their phylogenetic position and life strategies, we demonstrated that telomeres of trypanosomatids are diverse in length, even within groups of closely related species. Our analysis showed that the expression of two proteins predicted to be associated with telomeres (those encoding telomerase and telomere-associated hypothetical protein orthologous to Tb927.6.4330) may directly affect and account for the differences in telomere length within the species of the Leishmania mexicana complex. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2022 Electronic address https://www.cambridge.org/core/journals/parasitology/article/diverse-telomeres-in-trypanosomatids/A5F22C810DA8F772B7CB884834EB325E
Number of the records: 1