Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics

Švec, Pavel; Petrov, O. V.; Lang, J.; Štěpnička, P.; Groborz, Ondřej; Dunlop, David; Blahut, J.; Kolouchová, Kristýna; Loukotová, Lenka; Sedláček, O.; Heizer, T.; Tošner, Z.; Šlouf, Miroslav; Beneš, Hynek; Hoogenboom, R.; Hrubý, Martin

doi:https://dx.doi.org/10.1021/acs.macromol.1c01723

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Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics

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SYSNO ASEP	0552887
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics
Author(s)	Švec, Pavel (UMCH-V)_{RID, ORCID} Petrov, O. V. (CZ) Lang, J. (CZ) Štěpnička, P. (CZ) Groborz, Ondřej (UMCH-V)_{ORCID, RID} Dunlop, David (UFCH-W)_ORCID Blahut, J. (CZ) Kolouchová, Kristýna (UMCH-V)_{ORCID, RID} Loukotová, Lenka (UMCH-V)_{RID, ORCID} Sedláček, O. (CZ) Heizer, T. (CZ) Tošner, Z. (CZ) Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Beneš, Hynek (UMCH-V)_{RID, ORCID} Hoogenboom, R. (BE) Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	Macromolecules. - : American Chemical Society - ISSN 0024-9297 Roč. 55, č. 2 (2022), s. 658-671
Number of pages	14 s.
Language	eng - English
Country	US - United States
Keywords	fluorinated polymer ; ferrocene ; redox-responsive polymer
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Subject RIV - cooperation	J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry
R&D Projects	LTC19032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2018133 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA19-01438S GA ČR - Czech Science Foundation (CSF)
Research Infrastructure	EATRIS-CZ III - 90133 - Univerzita Palackého v Olomouci
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013 ; UFCH-W - RVO:61388955
UT WOS	000739491900001
EID SCOPUS	85122812925
DOI	10.1021/acs.macromol.1c01723
Annotation	Fluorine-19 magnetic resonance imaging (19F MRI) stands out as a powerful tool for noninvasive diagnostics. In particular, polymer-based 19F MRI tracers offer tunable physicochemical properties, including solubility and thermoresponsiveness, and enhanced 19F MRI performance. However, these tracers do not detectably respond to redox changes or do so in only one redox state, thereby preventing potential applications to reactive oxygen species (ROS) bioimaging. Herein, we report the first amphiphilic redox-responsive, poly(2-oxazoline)-based polymers bearing fluorinated ferrocene moieties. Their hydrophobicity and redox responsiveness were tailored by changing the monomer ratio and substitution pattern of the fluorinated ferrocene units. Converting the diamagnetic fluorinated ferrocene moieties into paramagnetic ferrocenium markedly changed the chemical shift and relaxation times of the 19F nuclei distinguishable by 19F MRI. In turn, the statistical–diblock copolymers formed nanoparticles that disassemble upon oxidation, with no toxicity to cultured cells. Therefore, these polymers may be used to release lipophilic drugs in ROS-rich malignancies.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2023
Electronic address	https://pubs.acs.org/doi/10.1021/acs.macromol.1c01723

Number of the records: 1