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Caged Phytohormones: From Chemical Inactivation to Controlled Physiological Response
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SYSNO ASEP 0552823 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Caged Phytohormones: From Chemical Inactivation to Controlled Physiological Response Author(s) Hemelíková, Noemi (UEB-Q) ORCID
Žukauskaitė, A. (CZ)
Pospíšil, T. (CZ)
Strnad, Miroslav (UEB-Q) RID, ORCID
Doležal, K. (CZ)
Mik, V. (CZ)Number of authors 6 Source Title Journal of Agricultural and Food Chemistry. - : American Chemical Society - ISSN 0021-8561
Roč. 69, č. 41 (2021), s. 12111-12125Number of pages 15 s. Language eng - English Country US - United States Keywords caged compound ; chemical biology ; photochemistry ; photoremovable protecting group ; phytohormone ; plant physiology OECD category Biochemistry and molecular biology R&D Projects EF16_019/0000827 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UEB-Q - RVO:61389030 UT WOS 000710964600005 EID SCOPUS 85117574247 DOI 10.1021/acs.jafc.1c02018 Annotation Plant hormones, also called phytohormones, are small signaling molecules regulating a wide range of growth and developmental processes. These unique compounds respond to both external (light, temperature, water, nutrition, or pathogen attack) and internal factors (e.g., age) and mediate signal transduction leading to gene expression with the aim of allowing plants to adapt to constantly changing environmental conditions. Within the regulation of biological processes, individual groups of phytohormones act mostly through a web of interconnected responses rather than linear pathways, making elucidation of their mode of action in living organisms quite challenging. To further progress with our knowledge, the development of novel tools for phytohormone research is required. Although plenty of small molecules targeting phytohormone metabolic or signaling pathways (agonists, antagonists, and inhibitors) and labeled or tagged (fluorescently, isotopically, or biotinylated) compounds have been produced, the control over them in vivo is lost at the time of their administration. Caged compounds, on the other hand, represent a new approach to the development of small organic substances for phytohormone research. The term caged compounds refers to light-sensitive probes with latent biological activity, where the active molecule can be freed using a light beam in a highly spatio/temporal-, amplitude-, or frequency-defined manner. This review summarizes the up-to-date development in the field of caged plant hormones. Research progress is arranged in chronological order for each phytohormone regardless of the cage compound formulation and bacterial/plant/animal cell applications. Several known drawbacks and possible directions for future research are highlighted. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2022 Electronic address http://doi.org/10.1021/acs.jafc.1c02018
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