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Cytotoxic effect of Aeruginosin-865, capsaicin, and resveratrol on mouse cell lines of different origin
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SYSNO ASEP 0552400 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cytotoxic effect of Aeruginosin-865, capsaicin, and resveratrol on mouse cell lines of different origin Author(s) Veselá, I. (CZ)
Cheel Horna, José (MBU-M)
Tomenendalová, J. (CZ)
Hamouzová, P. (CZ)
Hrouzek, Pavel (MBU-M) ORCID
Stehliková, S. (CZ)
Řeháková, K. (CZ)
Doubek, J. (CZ)Source Title Acta veterinaria Brno. - : Veterinární a farmaceutická univerzita Brno - ISSN 0001-7213
Roč. 90, č. 3 (2021), s. 307-314Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords anticancer properties ; apoptosis ; Alkaloids ; anticancer treatment ; natural bioactive compounds ; phenolics ; viability OECD category Veterinary science Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000735992600008 EID SCOPUS 85117239204 DOI 10.2754/avb202190030307 Annotation The aim of the study was to compare the effects of three natural bioactive compounds (and their combinations) on normal vs. tumour-transformed mouse cells. The cytotoxic effect of Aeruginosin-865 (Aer), capsaicin (Cap), resveratrol (Res) and their combinations was evaluated on normal hepatocytes (AML) and tumour cells derived from livers (Hepa) and kidneys (Renca). Various concentrations from 25 to 200 mu M of tested substances were used. Only the Aer + Res combination and a low concentration of Res had a significant cytotoxic effect on Hepa and Renca and no significant cytotoxic effect on AML. Cap had a significant cytotoxic effect on all tested cell lines, but tumour-derived cells showed higher resistance than AML. A significantly increased cytotoxicity was found in the combination of Cap + Res compared to each substance alone. All types of cells showed similar sensitivity to the cytotoxic effect of Cap + Res. Because of a possible hepatotoxic effect, we recommend further investigations into side-effects of Cap + Res. No cytotoxic effect was described in Cap + Aer or in Aer alone. Only substances with a significant cytotoxic effect on tumour cells and no cytotoxic effect on normal cells can be potentially used in anticancer treatment. According to the results, only Res or the combination of Aer + Res can be recommended for further evaluation in the process of new anticancer drug development. The potential hepatotoxic effect of Cap + Res can significantly limit the utilisation of these substances in anticancer treatment. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2022 Electronic address https://actavet.vfu.cz/90/3/0307/
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