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Age-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria

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    SYSNO ASEP0552140
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleAge-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria
    Author(s) Endlicher, R. (CZ)
    Drahota, Zdeněk (FGU-C) RID, ORCID
    Kučera, O. (CZ)
    Červinková, Z. (CZ)
    Source TitlePhysiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
    Roč. 70, č. 6 (2021), s. 905-911
    Number of pages7 s.
    Languageeng - English
    CountryCZ - Czech Republic
    Keywordsrat liver mitochondria ; mitochondrial permeability transition pore ; calcium retention capacity ; calcium-induced swelling
    OECD categoryPhysiology (including cytology)
    Method of publishingOpen access
    Institutional supportFGU-C - RVO:67985823
    UT WOS000735395600009
    EID SCOPUS85122449375
    DOI10.33549/physiolres.934734
    AnnotationMitochondria play an important role in the cell aging process. Changes in calcium homeostasis and/or increased reactive oxygen species (ROS) production lead to the opening of mitochondrial permeability transition pore (MPTP), depolarization of the inner mitochondrial membrane, and decrease of ATP production. Our work aimed to monitor age-related changes in the Ca2+ ion effect on MPTP and the ability of isolated rat liver mitochondria to accumulate calcium. The mitochondrial calcium retention capacity (CRC) was found to be significantly affected by the age of rats. Measurement of CRC values of the rat liver mitochondria showed two periods when 3 to 17-week old rats were tested. 3-week and 17-week old rats showed lower CRC values than 7-week old animals. Similar changes were observed while testing calcium-induced swelling of rat liver mitochondria. These findings indicate that the mitochondrial energy production system is more resistant to calcium-induced MPTP opening accompanied by the damaging effect of ROS in adult rats than in young and aged animals.
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2022
    Electronic addresshttps://www.biomed.cas.cz/physiolres/pdf/2021/70_905.pdf
Number of the records: 1