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Biological Soft Matter: Fundamentals, Properties, and Applications
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SYSNO ASEP 0550974 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Inorganic nanomaterials as promoters/inhibitors of amyloid fibril formation Author(s) Holubová, Monika (UMCH-V) ORCID, RID Source Title Biological Soft Matter: Fundamentals, Properties, and Applications. - Weinheim : Wiley-VCH, 2021 / Nardin C. ; Schlaad H. - ISBN 978-3-527-34348-5 Pages s. 195-228 Number of pages 34 s. Number of pages 288 Publication form Print - P Language eng - English Country DE - Germany Keywords amyloidogenecity ; fibrillar self-assembly ; polymer coating Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 Annotation The exposure of the human population to nanoparticles has been increasing. Inorganic nanoparticles easily penetrate the human body, are biologically active, have a large specific surface area and are able to persist in the environment and accumulate there. Many of them are also promoters/inhibitors of amyloid fibril formation. Amyloidoses are very serious diseases that are characterized by amyloid deposition in various organs and tissues causing their dysfunction. This review addresses the influence of inorganic nanoparticles on the process of amyloid fibril formation, which is a popular topic in nanoparticle science because of associated public health concerns. The effect of nanoparticles on amyloid fibril formation is dependent on several parameters such as nanoparticle size, shape and surface chemistry. It was found that the same type of nanoparticle may have different effects on the process of amyloid fibril formation depending on the model system used. They can promote the fibrillation of some model protein systems, but on the other hand, they can inhibit the fibrillation of others. Some nanoparticles can even decompose amyloid fibrils. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://www.wiley.com/en-ie/Biological+Soft+Matter:+Fundamentals,+Properties,+and+Applications-p-9783527343485
Number of the records: 1