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The Influence of High and Low Negative Pressure Liposuction and Various Harvesting Techniques on the Viability and Function of Harvested Cells-a Systematic Review of Animal and Human Studies
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SYSNO ASEP 0548716 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Influence of High and Low Negative Pressure Liposuction and Various Harvesting Techniques on the Viability and Function of Harvested Cells-a Systematic Review of Animal and Human Studies Author(s) Molitor, M. (CZ)
Trávníčková, Martina (FGU-C) RID, ORCID, SAI
Měšťák, O. (CZ)
Christodoulou, P. (CZ)
Sedlář, Antonín (FGU-C) ORCID
Bačáková, Lucie (FGU-C) RID, ORCID
Lucchina, S. (CH)Source Title Aesthetic Plastic Surgery - ISSN 0364-216X
Roč. 45, č. 5 (2021), s. 2379-2394Number of pages 16 s. Language eng - English Country US - United States Keywords adipocyte ; ADSC ; negative pressure ; liposuction ; fat grafting Subject RIV EI - Biotechnology ; Bionics OECD category Biomaterials (as related to medical implants, devices, sensors) R&D Projects NU20-08-00208 GA MZd - Ministry of Health (MZ) LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000641208300002 EID SCOPUS 85109039502 DOI 10.1007/s00266-021-02249-9 Annotation Background An understanding of fat grafting methodology, techniques and patient-related factors is crucial when considering fat grafting. Multiple factors can influence the success of a fat graft and consequently the outcome of the procedure. The aim of this systematic review is to elucidate the influence of negative pressure and various techniques of fat harvesting on the viability and function of cells, particularly adipocytes and adipose-derived stem cells. Methods We conducted a literature search from 1975 to 2020 using the PubMed bibliography, ScienceDirect, SCOPUS and the Google Scholar databases which produced 168,628 articles on the first pass. After applying all the exclusion criteria by two independent reviewers, we were left with 21 articles (level IV of Oxford Centre for Evidence-Based Studies and Grade C of Grade Practice Recommendation from the American Society of Plastic Surgeons) on which this review is based. Results From 11 studies focused on different negative pressures, no one found using high negative pressure advantageous. Summarising 13 studies focused on various harvesting techniques (excision, syringe, and pump-machine), most often equal results were reported, followed by excision being better than either syringe or liposuction. Conclusion From our systematic review, we can conclude that the low negative pressure seems to yield better results and that the excision seems to be the most sparing method for fat graft harvesting. However, we have to point out that this conclusion is based on a very limited number of statistically challengeable articles and we recommend well-conducted further research. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2022 Electronic address https://doi.org/10.1007/s00266-021-02249-9
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