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Neurodegenerative Diseases Biomarkers
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SYSNO ASEP 0548440 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Validation of Diffusion Kurtosis Imaging as an Early-Stage Biomarker of Parkinson’s Disease in Animal Models Author(s) Khairnar, A. (IN)
Dražanová, Eva (UPT-D) RID, ORCID, SAI
Szabó, N. (HU)
Rudá-Kučerová, J. (CZ)Source Title Neurodegenerative Diseases Biomarkers. - New York : Humana, 2022 / Peplow P. V. ; Martinez B. ; Gennarelli T. A. - ISBN 978-1-0716-1712-0 Pages s. 429-455 Number of pages 27 s. Number of pages 565 Publication form Online - E Language eng - English Country US - United States Keywords Diffusion kurtosis imaging ; Diffusion tensor imaging ; Magnetic resonance imaging ; Methamphetamine ; Microstructural changes ; Neurodegeneration ; α-Synuclein ; TNWT-61 Mice Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects EF16_013/0001775 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure Czech-BioImaging - 90062 - Ústav molekulární genetiky AV ČR, v. v. i. Institutional support UPT-D - RVO:68081731 UT WOS 000868553200020 EID SCOPUS 85117525934 DOI 10.1007/978-1-0716-1712-0_18 Annotation Diffusion kurtosis imaging (DKI), which is a mathematical extension of diffusion tensor imaging (DTI), assesses non-Gaussian water diffusion in the brain. DKI proved to be effective in supporting the diagnosis of different neurodegenerative disorders. Its sensitively detects microstructural changes in the brain induced by either protein accumulation, glial cell activation or neurodegeneration as observed in mouse models of Parkinson’s disease. We applied two experimental models of Parkinson’s disease to validate the diagnostic utility of DKI in early and late stage of disease pathology. We present two DKI analysis methods: (1) tract based spatial statistics (TBSS), which is a hypothesis independent data driven approach intended to evaluate white matter changes, and (2) region of interest (ROI) based analysis based on hypothesis of ROIs relevant for Parkinson’s disease, which is specifically used for gray matter changes. The main aim of this chapter is to provide detailed information of how to perform the DKI imaging acquisition and analysis in the mouse brain, which can be, to some extent translated to humans. Workplace Institute of Scientific Instruments Contact Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Year of Publishing 2023 Electronic address https://link.springer.com/protocol/10.1007%2F978-1-0716-1712-0_18
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