Chelators for treatment of iron and copper overload: shift from low-molecular-weight compounds to polymers

Hrubý, Martin; Martínez, I. I. S.; Stephan, H.; Poučková, P.; Beneš, J.; Štěpánek, Petr

doi:https://dx.doi.org/10.3390/polym13223969

Number of the records: 1

Chelators for treatment of iron and copper overload: shift from low-molecular-weight compounds to polymers

1.

SYSNO ASEP	0548168
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Chelators for treatment of iron and copper overload: shift from low-molecular-weight compounds to polymers
Author(s)	Hrubý, Martin (UMCH-V)_{RID, ORCID} Martínez, I. I. S. (DE) Stephan, H. (DE) Poučková, P. (CZ) Beneš, J. (CZ) Štěpánek, Petr (UMCH-V)_{RID, ORCID}
Article number	3969
Source Title	Polymers. - : MDPI Roč. 13, č. 22 (2021)
Number of pages	21 s.
Language	eng - English
Country	CH - Switzerland
Keywords	iron ; copper ; polymer
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	GA19-01438S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000724813200001
EID SCOPUS	85119718346
DOI	10.3390/polym13223969
Annotation	Iron and copper are essential micronutrients needed for the proper function of every cell. However, in excessive amounts, these elements are toxic, as they may cause oxidative stress, resulting in damage to the liver and other organs. This may happen due to poisoning, as a side effect of thalassemia infusion therapy or due to hereditary diseases hemochromatosis or Wilson’s disease. The current golden standard of therapy of iron and copper overload is the use of low-molecular-weight chelators of these elements. However, these agents suffer from severe side effects, are often expensive and possess unfavorable pharmacokinetics, thus limiting the usability of such therapy. The emerging concepts are polymer-supported iron- and copper-chelating therapeutics, either for parenteral or oral use, which shows vivid potential to keep the therapeutic efficacy of low-molecular-weight agents, while avoiding their drawbacks, especially their side effects. Critical evaluation of this new perspective polymer approach is the purpose of this review article.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2022
Electronic address	https://www.mdpi.com/2073-4360/13/22/3969

Number of the records: 1