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Molecular characterization of alcohol–ether extract from bovine tissue

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    SYSNO ASEP0545566
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve SCOPUS
    TitleMolecular characterization of alcohol–ether extract from bovine tissue
    Author(s) Kubelková, K. (CZ)
    Hubálek, Martin (UOCHB-X) RID, ORCID
    Řehulka, P. (CZ)
    Řehulková, H. (CZ)
    Friedecký, D. (CZ)
    Žáková, J. (CZ)
    Macela, A. (CZ)
    Source TitleMilitary Medical Science Letters - ISSN 0372-7025
    Roč. 90, č. 3 (2021), s. 120-136
    Number of pages17 s.
    Languageeng - English
    CountryCZ - Czech Republic
    Keywordsbovine tissue extract ; Juvenil ; molecular composition ; psychobiotics ; biological response modifier ; antimicrobial peptides ; defensin ; hemocidin
    OECD categoryAnalytical chemistry
    Method of publishingOpen access
    Institutional supportUOCHB-X - RVO:61388963
    EID SCOPUS85114640614
    DOI10.31482/mmsl.2021.012
    AnnotationIt is usual for information to be unavailable regarding the molecular composition of extracts from herbs or animal tissues that are popular in folk medicine. Here, we present analysis of the alcohol–ether extract from bovine tissue analogous to the basic substance used in such commercial products as Retisin, Imuregen, Actovegin, and Solcoseryl. The tested extract contains a whole spectrum of free amino acids, small proteins and oligopeptides of molecular weight up to 10 kDa, various nucleotides, and a small amount of phospholipids. Among the molecules that can explain some biological activities of the extract were identified those of taurine (2-aminoethanesulfonic acid, a derivative of the amino acid cysteine), several defensins, and bactericidal hemoglobin fragments known as hemocidins. All those molecules identified are natural components of bovine tissues, and a substantial number of them might be biologically active in vivo. Others are sources of readily available nutrients.
    WorkplaceInstitute of Organic Chemistry and Biochemistry
    Contactasep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
    Year of Publishing2022
    Electronic addresshttp://doi.org/10.31482/mmsl.2021.012
Number of the records: 1