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Molecular characterization of alcohol–ether extract from bovine tissue
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SYSNO ASEP 0545566 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve SCOPUS Title Molecular characterization of alcohol–ether extract from bovine tissue Author(s) Kubelková, K. (CZ)
Hubálek, Martin (UOCHB-X) RID, ORCID
Řehulka, P. (CZ)
Řehulková, H. (CZ)
Friedecký, D. (CZ)
Žáková, J. (CZ)
Macela, A. (CZ)Source Title Military Medical Science Letters. - : Univerzita obrany - ISSN 0372-7025
Roč. 90, č. 3 (2021), s. 120-136Number of pages 17 s. Language eng - English Country CZ - Czech Republic Keywords bovine tissue extract ; Juvenil ; molecular composition ; psychobiotics ; biological response modifier ; antimicrobial peptides ; defensin ; hemocidin OECD category Analytical chemistry Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 EID SCOPUS 85114640614 DOI 10.31482/mmsl.2021.012 Annotation It is usual for information to be unavailable regarding the molecular composition of extracts from herbs or animal tissues that are popular in folk medicine. Here, we present analysis of the alcohol–ether extract from bovine tissue analogous to the basic substance used in such commercial products as Retisin, Imuregen, Actovegin, and Solcoseryl. The tested extract contains a whole spectrum of free amino acids, small proteins and oligopeptides of molecular weight up to 10 kDa, various nucleotides, and a small amount of phospholipids. Among the molecules that can explain some biological activities of the extract were identified those of taurine (2-aminoethanesulfonic acid, a derivative of the amino acid cysteine), several defensins, and bactericidal hemoglobin fragments known as hemocidins. All those molecules identified are natural components of bovine tissues, and a substantial number of them might be biologically active in vivo. Others are sources of readily available nutrients. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2022 Electronic address http://doi.org/10.31482/mmsl.2021.012
Number of the records: 1