Number of the records: 1

Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery

SYSNO ASEP	0545469
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery
Author(s)	Hejdánková, Zuzana (UOCHB-X)_ORCID Vaněk, Václav (UOCHB-X)_{RID, ORCID} Sedlák, František (UOCHB-X)_{RID, ORCID} Procházka, Jan (UMG-J)_ORCID Diederichs, Audrey (UOCHB-X) Kereiche, Sami (UOCHB-X)_ORCID Novotná, Barbora (UOCHB-X)_ORCID Buděšínský, Miloš (UOCHB-X)_{RID, ORCID} Birkuš, Gabriel (UOCHB-X)_ORCID Grantz Šašková, Klára (UOCHB-X)_{RID, ORCID} Cígler, Petr (UOCHB-X)_{RID, ORCID}
Article number	2101391
Source Title	Advanced Functional Materials - ISSN 1616-301X Roč. 31, č. 47 (2021)
Number of pages	9 s.
Language	eng - English
Country	DE - Germany
Keywords	cyclic dinucleotides ; DNA ; drug delivery ; lipid nanoparticles ; RNA
OECD category	Biochemistry and molecular biology
R&D Projects	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	EF16_013/0001789 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	EF18_046/0015861 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED2.1.00/19.0395 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Limited access
Institutional support	UOCHB-X - RVO:61388963 ; UMG-J - RVO:68378050
UT WOS	000688518800001
EID SCOPUS	85113371724
DOI	10.1002/adfm.202101391
Annotation	Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane-based lipidoids named XMaNs, which circumvent the usual need for laborious optimization of LNP components for highly diverse types of NAs, are described. The non-toxic XMaN6 lipidoid is highly versatile in entrapment and delivery of siRNA, mRNA, plasmid DNA, and a cyclic dinucleotide. XMaN6-based LNPs efficiently deliver: 1) siRNA into human primary hepatocytes and cell lines that are hard-to-transfect, 2) mRNA into mouse liver, 3) plasmid DNA, 4) 2′,3′-cGAMP into cells and activated the cGAS-STING pathway three orders of magnitude more efficiently than 2′,3′-cGAMP alone. To our knowledge, such universality in delivering different NA types has not been previously described and can accelerate translation of LNPs into the clinic.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2022
Electronic address	https://doi.org/10.1002/adfm.202101391

Number of the records: 1