Number of the records: 1
Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting
- 1.
SYSNO ASEP 0545464 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting Author(s) Černotová, Daniela (FGU-C) ORCID
Stuchlík, Aleš (FGU-C) RID, ORCID
Svoboda, Jan (FGU-C) RID, ORCIDArticle number 107477 Source Title Neurobiology of Learning and Memory. - : Elsevier - ISSN 1074-7427
Roč. 183, September 2021 (2021)Number of pages 10 s. Language eng - English Country US - United States Keywords behavioral flexibility ; ventral hippocampus ; prefrontal cortex ; Muscimol ; rotating arena ; carousel Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects NV17-30833A GA MZd - Ministry of Health (MZ) GA20-00939S GA ČR - Czech Science Foundation (CSF) LTAUSA19135 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000681199700009 EID SCOPUS 85107988227 DOI 10.1016/j.nlm.2021.107477 Annotation Neural components enabling flexible cognition and behavior are well-established, and depend mostly on proper intercommunication within the prefrontal cortex (PFC) and striatum. However, dense projections from the ventral hippocampus (vHPC) alter the functioning of the medial PFC (mPFC). Dysfunctional hippocampo-prefrontal connectivity negatively affects the integrity of flexible cognition, especially in patients with schizophrenia. In this study, we aimed to test the role of the vHPC and mPFC in a place avoidance task on a rotating arena using two spatial flexibility task variants – reversal learning and set-shifting. To achieve this, we inactivated each of these structures in adult male Long-Evans rats by performing bilateral local muscimol (a GABAA receptor agonist) injections. A significantly disrupted performance was observed in reversal learning in the vHPC-inactivated, but not in the mPFC-inactivated rats. These results confirm the notion that the vHPC participates in some forms of behavioral flexibility, especially when spatial cues are needed. It seems, rather unexpectedly, that the mPFC is not taxed in these flexibility tasks on a rotating arena. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2022 Electronic address https://doi.org/10.1016/j.nlm.2021.107477
Number of the records: 1