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Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy
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SYSNO ASEP 0545023 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy Author(s) Germano, J. F. (US)
Sharma, A. (NO)
Šťastná, Miroslava (UIACH-O) RID, ORCID
Huang, C. (US)
Aniag, M. (US)
Aceves, A. (US)
Van Eyk, J.E. (US)
Mentzer, R. M. (US)
Piplani, H. (US)
Andres, A. M. (US)
Gottlieb, R. A. (US)Number of authors 11 Article number 8711 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 16 (2021)Number of pages 21 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords glucagon-like peptide-1 receptor agonists (GLP1Ras) ; proteomics ; early cardiac remodeling Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry Method of publishing Limited access Institutional support UIACH-O - RVO:68081715 UT WOS 000689131200001 EID SCOPUS 85112352761 DOI 10.3390/ijms22168711 Annotation The global proteomics was employed to interrogate the target proteins, organelles and biological processes affected by short-acting GLP1Ra administered after permanent coronary artery ligation (PCAL).This approach showed a central role for mitochondria and mitochondria-associated metabolic pathways, such as fatty acid oxidation, in the beneficial effects of short-acting GLP1Ra on postinfarttion remodeling. The overexpression of proteins identified by protein-protein interaction networks, such as Atp2a2, may be important to the mechanism of action of GLP1Ra. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2022 Electronic address http://hdl.handle.net/11104/0321801
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