Number of the records: 1
Polarization-resolved second-harmonic generation imaging through a multimode fiber
- 1.
SYSNO ASEP 0544708 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polarization-resolved second-harmonic generation imaging through a multimode fiber Author(s) Cifuentes, Angel S. (UPT-D) RID, SAI, ORCID
Pikálek, Tomáš (UPT-D) RID, ORCID, SAI
Ondráčková, Petra (UPT-D)
Amezcua-Correa, R. (US)
Antonio-Lopez, J. E. (US)
Čižmár, Tomáš (UPT-D) RID, ORCID, SAI
Traegaardh, Johanna (UPT-D) RID, ORCID, SAINumber of authors 7 Source Title Optica. - : Optical Society of America - ISSN 2334-2536
Roč. 8, č. 8 (2021), s. 1065-1074Number of pages 10 s. Publication form Online - E Language eng - English Country US - United States Keywords second harmonic generation ; multimode fiber ; bioimaging ; polarization control Subject RIV BH - Optics, Masers, Lasers OECD category Optics (including laser optics and quantum optics) R&D Projects EF15_003/0000476 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED0017/01/01 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1212 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UPT-D - RVO:68081731 UT WOS 000687747700005 EID SCOPUS 85111981587 DOI 10.1364/OPTICA.430295 Annotation Multimode fiber-based endoscopes have recently emerged as a tool for minimally invasive endoscopy in tissue, at depths well beyond the reach of multiphoton imaging. Here, we demonstrate label-free second-harmonic generation (SHG) microscopy through such a fiber endoscope. We simultaneously fully control the excitation polarization state and the spatial distribution of the light at the fiber tip, and we use this to implement polarization-resolved SHG imaging, which allows imaging and identification of structural proteins such as collagen and myosin.We image mouse tail tendon and heart tissue, employing the endoscope at depths up to 1 mm, demonstrating that we can differentiate these structural proteins. This method has the potential for enabling instant and in situ diagnosis of tumors and fibrotic conditions insensitive tissue with minimal damage. Workplace Institute of Scientific Instruments Contact Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Year of Publishing 2022 Electronic address https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-8-8-1065&id=453930
Number of the records: 1