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Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility

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    SYSNO ASEP0544582
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleExpression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility
    Author(s) Xing, L. (DE)
    Kubik-Zahorodna, Agnieszka (UMG-J)
    Namba, T. (DE)
    Pinson, A. (DE)
    Florio, M. (DE)
    Procházka, Jan (UMG-J)
    Sarov, M. (DE)
    Sedláček, Radislav (UMG-J) RID
    Huttner, W.B. (DE)
    Number of authors9
    Article numbere107093
    Source TitleEMBO Journal - ISSN 0261-4189
    Roč. 40, č. 13 (2021)
    Number of pages17 s.
    Publication formOnline - E
    Languageeng - English
    CountryGB - United Kingdom
    Keywordsbasal progenitors ; brain evolution ; human‐ ; specific gene ; memory flexibility ; neocortex expansion
    Subject RIVEB - Genetics ; Molecular Biology
    OECD categoryBiology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
    R&D ProjectsLM2018126 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    ED1.1.00/02.0109 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    ED2.1.00/19.0395 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    Method of publishingOpen access
    Institutional supportUMG-J - RVO:68378050
    UT WOS000646146900001
    AnnotationNeocortex expansion during human evolution provides a basis for our enhanced cognitive abilities. Yet, which genes implicated in neocortex expansion are actually responsible for higher cognitive abilities is unknown. The expression of human-specific ARHGAP11B in embryonic/foetal mouse, ferret and marmoset neocortex was previously found to promote basal progenitor proliferation, upper-layer neuron generation and neocortex expansion during development, features commonly thought to contribute to increased cognitive abilities. However, a key question is whether this phenotype persists into adulthood and if so, whether cognitive abilities are indeed increased. Here, we generated a transgenic mouse line with physiological ARHGAP11B expression that exhibits increased neocortical size and upper-layer neuron numbers persisting into adulthood. Adult ARHGAP11B-transgenic mice showed altered neurobehaviour, notably increased memory flexibility and a reduced anxiety level. Our data are consistent with the notion that neocortex expansion by ARHGAP11B, a gene implicated in human evolution, underlies some of the altered neurobehavioural features observed in the transgenic mice, such as the increased memory flexibility, a neocortex-associated trait, with implications for the increase in cognitive abilities during human evolution.
    WorkplaceInstitute of Molecular Genetics
    ContactGabriela Marešová,, Tel.: 241 063 217
    Year of Publishing2022
    Electronic address
Number of the records: 1