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Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility
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SYSNO ASEP 0544582 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility Author(s) Xing, L. (DE)
Kubik-Zahorodna, Agnieszka (UMG-J)
Namba, T. (DE)
Pinson, A. (DE)
Florio, M. (DE)
Procházka, Jan (UMG-J) ORCID
Sarov, M. (DE)
Sedláček, Radislav (UMG-J) RID
Huttner, W.B. (DE)Number of authors 9 Article number e107093 Source Title EMBO Journal. - : Wiley - ISSN 0261-4189
Roč. 40, č. 13 (2021)Number of pages 17 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords basal progenitors ; brain evolution ; human‐ ; specific gene ; memory flexibility ; neocortex expansion Subject RIV EB - Genetics ; Molecular Biology OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology R&D Projects LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED2.1.00/19.0395 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000646146900001 DOI 10.15252/embj.2020107093 Annotation Neocortex expansion during human evolution provides a basis for our enhanced cognitive abilities. Yet, which genes implicated in neocortex expansion are actually responsible for higher cognitive abilities is unknown. The expression of human-specific ARHGAP11B in embryonic/foetal mouse, ferret and marmoset neocortex was previously found to promote basal progenitor proliferation, upper-layer neuron generation and neocortex expansion during development, features commonly thought to contribute to increased cognitive abilities. However, a key question is whether this phenotype persists into adulthood and if so, whether cognitive abilities are indeed increased. Here, we generated a transgenic mouse line with physiological ARHGAP11B expression that exhibits increased neocortical size and upper-layer neuron numbers persisting into adulthood. Adult ARHGAP11B-transgenic mice showed altered neurobehaviour, notably increased memory flexibility and a reduced anxiety level. Our data are consistent with the notion that neocortex expansion by ARHGAP11B, a gene implicated in human evolution, underlies some of the altered neurobehavioural features observed in the transgenic mice, such as the increased memory flexibility, a neocortex-associated trait, with implications for the increase in cognitive abilities during human evolution. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2022 Electronic address https://www.embopress.org/doi/full/10.15252/embj.2020107093
Number of the records: 1