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Five Commercial Immunoassays for SARS-CoV-2 Antibody Determination and Their Comparison and Correlation with the Virus Neutralization Test
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SYSNO ASEP 0544580 Document Type J - Journal Article R&D Document Type The record was not marked in the RIV Subsidiary J Ostatní články Title Five Commercial Immunoassays for SARS-CoV-2 Antibody Determination and Their Comparison and Correlation with the Virus Neutralization Test Author(s) Šimánek, V. (CZ)
Pecen, Ladislav (UIVT-O) RID, SAI, ORCID
Krátká, Z. (CZ)
Fürst, T. (CZ)
Řezáčková, H. (CZ)
Topolčan, O. (CZ)
Fajfrlík, K. (CZ)
Sedláček, D. (CZ)
Šín, R. (CZ)
Pazdiora, P. (CZ)
Zelená, H. (CZ)
Slouka, D. (CZ)
Kučera, R. (CZ)Article number 593 Source Title Diagnostics. - : MDPI
Roč. 11, č. 4 (2021)Number of pages 14 s. Language eng - English Country CH - Switzerland Keywords SARS-CoV-2 ; antibody ; immunoassay ; nucleocapsid protein ; serological diagnostics ; spike protein ; virus neutralization test Method of publishing Open access DOI 10.3390/diagnostics11040593 Annotation There is an ongoing debate as to whether SARS-CoV-2 antibodies can be found in patients who have recovered from COVID-19 disease. Currently, there is no consensus on whether the antibodies, if present, are protective. Our regular measurements of SARS-CoV-2 antibodies, starting in July 2020, have provided us with the opportunity of becoming acquainted with the five different immunoassays. A total of 149 patients were enrolled in our study. We measured the samples using each immunoassay, then performing a virus neutralization test and comparing the results of SARS-CoV-2 antibodies with this test. We observed that the production of neutralizing antibodies is age-dependent. Elderly patients have a higher proportion of high neutralizing titers than young patients. Based on our results, and in combination with the literature findings, we can conclude that the serological SARS-CoV-2 antibody measurement is a helpful tool in the fight against COVID-19. The assays can provide information about the patient's previous contact with the virus. Anti-spike protein assays correlate well with the virus neutralization test and can be used in the screening of potential convalescent plasma donors. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2022
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