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Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions
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SYSNO ASEP 0544568 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions Author(s) Valeš, Karel (FGU-C) RID, ORCID, SAI
Holubová, K. (CZ)Article number 136098 Source Title Neuroscience Letters. - : Elsevier - ISSN 0304-3940
Roč. 761, Sep 14 (2021)Number of pages 7 s. Language eng - English Country IE - Ireland Keywords schizophrenia ; antipsychotics ; cognition ; Morris water maze ; pre-pulse inhibition ; MK-801 Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects EF16_025/0007444 GA MZd - Ministry of Health (MZ) GA18-09296S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000672856300001 EID SCOPUS 85110107795 DOI 10.1016/j.neulet.2021.136098 Annotation Schizophrenia is a debilitating mental disorder characterized by positive, negative and cognitive symptoms. Whereas positive symptoms are satisfactorily addressed by current antipsychotic treatment, negative and cognitive symptomatic treatment remains largely ineffective. This review investigates the treatment efficacy regarding cognitive symptoms and evaluates the contribution of different monoamine receptor systems involved in schizophrenia pathophysiology to cognition. In the review, we included preclinical studies assessing the effect of different treatments on cognition in pre-pulse inhibition and two spatial cognitive tests. While pre-pulse inhibition investigates pre-attentive processes operating outside of conscious awareness, the spatial tasks require continuous attention and active engagement in task solving for a successful outcome. The schizophrenia-like phenotype was attained by acute or subchronic administration of non-competitive NMDA receptor antagonist MK-801. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2022 Electronic address https://doi.org/10.1016/j.neulet.2021.136098
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