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Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles
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SYSNO ASEP 0544174 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles Author(s) Gorshkova, Y. (RU)
Barbinta-Patrascu, M.-E. (RO)
Bokuchava, G. (RU)
Badea, N. (RO)
Ungureanu, C. (RO)
Lazea-Stoyanova, A. (RO)
Raileanu, M. (RO)
Bacalum, M. (RO)
Turchenko, V. (RU)
Zhigunov, Alexander (UMCH-V) RID, ORCID
Juszyńska-Galazka, E. (PL)Article number 1811 Source Title Nanomaterials. - : MDPI
Roč. 11, č. 7 (2021)Number of pages 25 s. Language eng - English Country CH - Switzerland Keywords silver/silver chloride nanoparticles ; “green” synthesis ; chlorophyll-a-labeled bio-inspired membranes Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000676478400001 EID SCOPUS 85109472738 DOI 10.3390/nano11071811 Annotation Silver/silver chloride nanoparticles (Ag/AgClNPs), with a mean size of 48.2 ± 9.5 nm and a zeta potential value of −31.1 ± 1.9 mV, obtained by the Green Chemistry approach from a mixture of nettle and grape extracts, were used as “building blocks” for the “green” development of plasmonic biohybrids containing biomimetic membranes and chitosan. The mechanism of biohybrid formation was elucidated by optical analyses (UV–vis absorption and emission fluorescence, FTIR, XRD, and SAXS) and microscopic techniques (AFM and SEM). The aforementioned novel materials showed a free radical scavenging capacity of 75% and excellent antimicrobial properties against Escherichia coli (IGZ = 45 mm) and Staphylococcus aureus (IGZ = 35 mm). The antiproliferative activity of biohybrids was highlighted by a therapeutic index value of 1.30 for HT-29 cancer cells and 1.77 for HepG2 cancer cells. At concentrations below 102.2 µM, these materials are not hemolytic, so they will not be harmful when found in the bloodstream. In conclusion, hybrid systems based on phyto-Ag/AgClNPs, artificial cell membranes, and chitosan can be considered potential adjuvants in liver and colorectal cancer treatment. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://www.mdpi.com/2079-4991/11/7/1811
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