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Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1
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SYSNO ASEP 0544140 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1 Author(s) Fabišik, Matěj (UMG-J)
Turečková, Jolana (UMG-J) RID
Pavliuchenko, Nataliia (UMG-J)
Králová, Jarmila (UMG-J)
Balounová, Jana (UMG-J)
Vičíková, Kristína (UMG-J)
Skopcová, Tereza (UMG-J)
Špoutil, František (UMG-J)
Pokorná, Jana (UMG-J)
Angelisová, Pavla (UMG-J) RID
Malissen, B. (FR)
Procházka, Jan (UMG-J) ORCID
Sedláček, Radislav (UMG-J) RID
Brdička, Tomáš (UMG-J) RIDNumber of authors 14 Article number 618332 Source Title Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 12, April (2021)Number of pages 12 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords lst1 ; inflammation ; colitis ; inflammatory bowel disease ; myeloid cells Subject RIV EB - Genetics ; Molecular Biology OECD category Immunology R&D Projects GBP302/12/G101 GA ČR - Czech Science Foundation (CSF) LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED2.1.00/19.0395 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_013/0001789 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000648897300001 DOI 10.3389/fimmu.2021.618332 Annotation LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved in cytoskeleton regulation and generation of tunneling nanotubes. LST1 gene is located in MHCIII locus close to many immunologically relevant genes. In addition, its expression increases under inflammatory conditions such as viral infection, rheumatoid arthritis and inflammatory bowel disease and its deficiency was shown to result in slightly increased sensitivity to influenza infection in mice. However, little else is known about its role in the immune system homeostasis and immune response. Here we show that similar to humans, LST1 is expressed in mice in the cells of the myeloid lineage. In vivo, its deficiency results in alterations in multiple leukocyte subset abundance in steady state and under inflammatory conditions. Moreover, LST1-deficient mice show significant level of resistance to dextran sodium sulphate (DSS) induced acute colitis, a model of inflammatory bowel disease. These data demonstrate that LST1 regulates leukocyte abundance in lymphoid organs and inflammatory response in the gut. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2022 Electronic address https://www.frontiersin.org/articles/10.3389/fimmu.2021.618332/full
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