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A cellular and spatial map of the choroid plexus across brain ventricles and ages
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SYSNO ASEP 0544117 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A cellular and spatial map of the choroid plexus across brain ventricles and ages Author(s) Dani, N. (US)
Herbst, R.H. (US)
McCabe, C. (US)
Green, G.S. (IL)
Kaiser, K. (CZ)
Head, J.P. (US)
Cui, J. (US)
Shipley, F.B. (US)
Jang, A. (US)
Dionne, D. (US)
Nguyen l, L. (US)
Rodman, C. (US)
Riesenfeld, S.J. (US)
Procházka, Jan (UMG-J) ORCID
Procházková, Michaela (UMG-J)
Sedláček, Radislav (UMG-J) RID
Zhang, F. (US)
Bryja, V. (CZ)
Rozenblatt-Rosen, O. (US)
Habib, N. (IL)
Regev, A. (US)
Lehtinen, M.K. (US)Number of authors 22 Source Title Cell. - : Cell Press - ISSN 0092-8674
Roč. 184, č. 11 (2021), s. 3056-3074Number of pages 19 s. Publication form Online - E Language eng - English Country US - United States Keywords gene-expression ; rhombic lip ; roof plate ; spi-c ; barrier ; differentiation ; inflammation ; macrophages ; recruitment ; activation Subject RIV EB - Genetics ; Molecular Biology OECD category Developmental biology R&D Projects LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED2.1.00/19.0395 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_013/0001789 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UMG-J - RVO:68378050 UT WOS 000656965600019 DOI 10.1016/j.cell.2021.04.003 Annotation The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1 beta (IL-1 beta) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2022 Electronic address https://www.cell.com/cell/fulltext/S0092-8674(21)00438-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867421004384%3Fshowall%3Dtrue
Number of the records: 1