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Engineering of pH-triggered nanoplatforms based on novel poly(2-methyl-2-oxazoline)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymers with tunable morphologies for biomedical applications

SYSNO ASEP	0542466
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Engineering of pH-triggered nanoplatforms based on novel poly(2-methyl-2-oxazoline)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymers with tunable morphologies for biomedical applications
Author(s)	Černoch, Peter (UMCH-V)_{RID, ORCID} Jäger, Alessandro (UMCH-V)_{RID, ORCID} Černochová, Zulfiya (UMCH-V)_{RID, ORCID} Sincari, Vladimir (UMCH-V)_{ORCID, RID} Albuquerque, L. J. C. (BR) Konefal, Rafal (UMCH-V)_{RID, ORCID} Pavlova, Ewa (UMCH-V)_RID Giacomelli, F. C. (BR) Jäger, Eliezer (UMCH-V)_{ORCID, RID}
Source Title	Polymer Chemistry . - : Royal Society of Chemistry - ISSN 1759-9954 Roč. 12, č. 19 (2021), s. 2868-2880
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	poly(2-methyl-2-oxazoline) ; poly[2-(diisopropylamino)ethyl methacrylate] ; diblock copolymers
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	GC20-15479J GA ČR - Czech Science Foundation (CSF)
	GJ20-13946Y GA ČR - Czech Science Foundation (CSF)
	GJ20-15077Y GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000642583400001
EID SCOPUS	85106186227
DOI	10.1039/D1PY00141H
Annotation	A two-step synthetic approach via the combination of living cationic ring-opening (CROP) and reversible addition–fragmentation chain transfer (RAFT) polymerization techniques was used to produce novel amphiphilic block copolymers based on the water-soluble poly(2-methyl-2-oxazoline) (PMeOx), which holds protein repelling properties, linked to the hydrophilic–hydrophobic pH-responsive block poly[2-(diisopropylamino)ethyl methacrylate] (PDPA). Hydrodynamic flow focusing nanoprecipitation microfluidics (MF) was further employed to manufacture block copolymer self-assemblies. Interestingly, although all the synthesized macromolecules contained higher amounts of the pH-responsive segment, the microfluidic approach allowed the manufacturing of core–shell micelles and polymersomes. The morphology seems to be driven by the overall molecular weight of the block copolymers rather than by the hydrophilic-to-hydrophobic weight ratio. Longer and shorter amphiphilic chains enabled the manufacturing of core–shell assemblies and polymeric vesicles, respectively. The use of PMeOx and PDPA blocks confers serum stability and pH-responsive behavior to the nanoparticles in a pH window which is particularly useful for tumour detection and therapy. The self-assembled nanostructures are non-toxic even at fairly high polymer concentrations. All these features therefore can be useful in the design of pH-triggered nanoplatforms of distinct morphologies towards a variety of biomedical applications, for instance, the loading and delivery of hydrophobic and hydrophilic therapeutics.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2022
Electronic address	https://pubs.rsc.org/en/content/articlelanding/2021/PY/D1PY00141H#!divAbstract

Number of the records: 1