Number of the records: 1  

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

  1. 1.
    SYSNO ASEP0542465
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleHunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy
    Author(s) Breinlinger, S. (DE)
    Phillips, T. J. (US)
    Haram, B. N. (US)
    Mareš, Jan (MBU-M) ORCID
    Yerena, J. A. M. (CZ)
    Hrouzek, Pavel (MBU-M) ORCID
    Sobotka, Roman (MBU-M) RID, ORCID
    Henderson, W. M. (US)
    Schmieder, P. (DE)
    Williams, S. M. (US)
    Lauderdale, J. D. (US)
    Wilde, H. D. (US)
    Gerrin, W. (US)
    Kust, A. (CZ)
    Washington, J. W. (US)
    Wagner, C. (DE)
    Geier, B. (DE)
    Liebeke, M. (DE)
    Enke, H. (DE)
    Niedermeyer, T. H. J. (DE)
    Wilde, S. B. (US)
    Article number1335
    Source TitleScience. - : American Association for the Advancement of Science - ISSN 0036-8075
    Roč. 371, č. 6536 (2021)
    Number of pages9 s.
    Languageeng - English
    CountryUS - United States
    Keywordseagle ; cyanobacterial neurotoxin ; vacuolar myelinopathy
    Subject RIVEE - Microbiology, Virology
    OECD categoryMicrobiology
    R&D ProjectsGC19-21649J GA ČR - Czech Science Foundation (CSF)
    Method of publishingOpen access
    Institutional supportMBU-M - RVO:61388971
    UT WOS000636043400031
    EID SCOPUS85103521011
    DOI10.1126/science.aax9050
    AnnotationVacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production.
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2022
    Electronic addresshttps://science.sciencemag.org/content/371/6536/eaax9050.abstract
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.