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Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy
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SYSNO ASEP 0542465 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy Author(s) Breinlinger, S. (DE)
Phillips, T. J. (US)
Haram, B. N. (US)
Mareš, Jan (MBU-M) ORCID
Yerena, J. A. M. (CZ)
Hrouzek, Pavel (MBU-M) ORCID
Sobotka, Roman (MBU-M) RID, ORCID
Henderson, W. M. (US)
Schmieder, P. (DE)
Williams, S. M. (US)
Lauderdale, J. D. (US)
Wilde, H. D. (US)
Gerrin, W. (US)
Kust, A. (CZ)
Washington, J. W. (US)
Wagner, C. (DE)
Geier, B. (DE)
Liebeke, M. (DE)
Enke, H. (DE)
Niedermeyer, T. H. J. (DE)
Wilde, S. B. (US)Article number 1335 Source Title Science. - : American Association for the Advancement of Science - ISSN 0036-8075
Roč. 371, č. 6536 (2021)Number of pages 9 s. Language eng - English Country US - United States Keywords eagle ; cyanobacterial neurotoxin ; vacuolar myelinopathy Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects GC19-21649J GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000636043400031 EID SCOPUS 85103521011 DOI 10.1126/science.aax9050 Annotation Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2022 Electronic address https://science.sciencemag.org/content/371/6536/eaax9050.abstract
Number of the records: 1