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In vitro cellular activity of maghemite/cerium oxide magnetic nanoparticles with antioxidant properties
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SYSNO ASEP 0542274 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title In vitro cellular activity of maghemite/cerium oxide magnetic nanoparticles with antioxidant properties Author(s) Moskvin, Maksym (UMCH-V) RID, ORCID
Huntošová, V. (SK)
Herynek, V. (CZ)
Matouš, P. (CZ)
Michalcová, A. (CZ)
Lobaz, Volodymyr (UMCH-V) RID, ORCID
Zasońska, Beata Anna (UMCH-V) RID, ORCID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Seliga, R. (SK)
Horák, Daniel (UMCH-V) RID, ORCIDArticle number 111824 Source Title Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765
Roč. 204, August (2021)Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords maghemite ; cerium oxide ; oxidative stress Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GC20-02177J GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000670362700009 EID SCOPUS 85107633728 DOI 10.1016/j.colsurfb.2021.111824 Annotation Magnetic γ-Fe2O3/CeO2 nanoparticles were obtained by precipitation of Ce(NO3)3 with ammonia in the presence of γ-Fe2O3 seeds. The formation of CeO2 nanoparticles on the seeds was confirmed by transmission electron microscopy linked with selected area electron diffraction, energy-dispersive X-ray spectroscopy, electron energy loss spectroscopy, and dynamic light scattering. The γ-Fe2O3/CeO2 particle surface was functionalized with PEG-neridronate to improve the colloidal stability in PBS and biocompatibility. Chemical and in vitro biological assays proved that the nanoparticles, due to the presence of cerium oxide, effectively scavenged radicals, thus decreasing oxidative stress in the model cell line. PEG functionalization of the nanoparticles diminished their in vitro aggregation and facilitated lysosomal cargo degradation in cancer cells during autophagy, which resulted in concentration-dependent cytotoxicity of the nanoparticles. Finally, the iron oxide core allowed easy magnetic separation of the particles from liquid media and may enable monitoring of nanoparticle biodistribution in organisms using magnetic resonance imaging. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S092777652100268X?via%3Dihub
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