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A water-soluble octahedral molybdenum cluster complex as a potential agent for X-ray induced photodynamic therapy

SYSNO ASEP	0542214
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A water-soluble octahedral molybdenum cluster complex as a potential agent for X-ray induced photodynamic therapy
Author(s)	Kirakci, Kaplan (UACH-T)_{SAI, RID, ORCID} Pozmogova, T.N. (RU) Protasevich, E. T. (RU) Vavilov, G. D. (RU) Stassen, A. P. M. (NL) Shestopalov, M.A. (RU) Lang, Kamil (UACH-T)_{SAI, RID, ORCID}
Number of authors	7
Source Title	Biomaterials Science . - : Royal Society of Chemistry - ISSN 2047-4830 Roč. 9, č. 8 (2021), s. 2893-2902
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	Cellular internalization ; Luminescence ; Photodynamic therapy ; Sodium compounds ; Transition metals
Subject RIV	CA - Inorganic Chemistry
OECD category	Inorganic and nuclear chemistry
R&D Projects	GA18-05076S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UACH-T - RVO:61388980
UT WOS	000641683300029
EID SCOPUS	85104609513
DOI	10.1039/d0bm02005b
Annotation	X-ray-induced photodynamic therapy (X-PDT) has recently evolved into a suitable modality to fight cancer. This technique, which exploits radiosensitizers producing reactive oxygen species, allows for a reduction of the radiation dose needed to eradicate cancer in the frame of the radiotherapy treatment of deep tumors. The use of transition metal complexes able to directly produce singlet oxygen, O2(1Δg), upon X-ray irradiation constitutes a promising route towards the optimization of the radiosensitizer's architecture. In our endeavour to conceive pertinent agents for X-PDT, we designed an octahedral molybdenum cluster complex (Mo6) with iodine inner ligands, and carboxylated apical ligands bearing ethylene oxide organic functions. The sodium salt of this complex is highly soluble in aqueous media and displays red luminescence which is efficiently quenched by oxygen to produce O2(1Δg) in a high quantum yield. Furthermore, due to its high radiodensity, the complex exhibits radioluminescence in aqueous media, with the same spectral features as for photoluminescence, indicating the production of O2(1Δg) upon X-ray irradiation. The uptake of the complex by Hep-2 and MRC-5 cells is negligible during the first hours of incubation, then considerably increases in connection with the hydrolysis of the apical ligands. The complex exhibits low toxicity in vitro and induces a radiotoxic effect, noticeable against cancerous Hep-2 cells but negligible against normal MRC-5 cells, at X-ray doses that do not affect cell viability otherwise. The first evaluation of in vivo toxicity of an Mo6 complex on a mouse model evidences a moderate and delayed toxic effect on kidneys, with an intravenous LD50 value of 390 ± 30 mg kg-1, possibly connected with hydrolysis-induced aggregation of the complex. Overall, this complex displays attractive features as a singlet oxygen radiosensitizer for X-PDT, highlighting the potential of transition metal cluster complexes towards this modality.
Workplace	Institute of Inorganic Chemistry
Contact	Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931
Year of Publishing	2022
Electronic address	https://doi.org/10.1039/D0BM02005B

Number of the records: 1