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Cyclotriphosphazene-based star copolymers as structurally tunable nanocarriers with programmable biodegradability
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SYSNO ASEP 0541739 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cyclotriphosphazene-based star copolymers as structurally tunable nanocarriers with programmable biodegradability Author(s) Androvič, Ladislav (UMCH-V) ORCID
Woldřichová, Lucie (UMCH-V) ORCID
Jozefjaková, Klaudia (UMCH-V)
Pechar, Michal (UMCH-V) RID, ORCID
Lynn, G. M. (US)
Kaňková, Dana (UMCH-V)
Malinová, L. (CZ)
Laga, Richard (UMCH-V) RID, ORCIDSource Title Macromolecules. - : American Chemical Society - ISSN 0024-9297
Roč. 54, č. 7 (2021), s. 3139-3157Number of pages 19 s. Language eng - English Country US - United States Keywords cyclotriphosphazene derivatives ; hydrophilic polymers ; biodegradable nanoparticle carriers Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LTAUSA18173 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-08176S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000640891600013 EID SCOPUS 85104977140 DOI 10.1021/acs.macromol.0c02889 Annotation Myriad nanocarriers have been developed to improve the therapeutic index of low-molecular-weight drugs for cancer treatment, but many have suboptimal size and/or are too stable for optimal penetration into tumors and their subsequent excretion from the body. To address this challenge, we developed a series of novel nanocarriers based on star polymers consisting of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(ethylene glycol) (PEG) polymer arms attached to hexavalent cyclotriphosphazene (CTP)-derived cores through either stable or stimuli-responsive linkers. The star polymers were assembled using either “grafting from” or “grafting onto” approaches and characterized by quantitative arm substitution at the core. The resulting star polymers were precisely defined water-soluble nanomaterials with a suitable hydrodynamic size (∼10–25 nm) for tumor uptake, those with stimuli-responsive linkers exhibited programmable pH- or cathepsin-mediated degradability. Finally, low-molecular-weight drugs—an anthracycline-based cancerostatic and an imidazoquinoline-based immunostimulant—were linked to exemplary CTP-based star polymers to demonstrate their suitability for drug delivery. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://pubs.acs.org/doi/10.1021/acs.macromol.0c02889
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