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Zwitterionic polyaspartamides based on L-lysine side-chain moieties: synthesis, nonfouling properties and direct/indirect nanogel preparation
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SYSNO ASEP 0540931 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Zwitterionic polyaspartamides based on L-lysine side-chain moieties: synthesis, nonfouling properties and direct/indirect nanogel preparation Author(s) Hladysh, Sviatoslav (UMCH-V) RID, ORCID
Oleshchuk, Diana (UMCH-V) ORCID
Dvořáková, Jana (UMCH-V) RID, ORCID
Golunova, Anna (UMCH-V) RID, ORCID
Šálek, Petr (UMCH-V) RID, ORCID
Pánek, Jiří (UMCH-V) RID, ORCID
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Kaňková, Dana (UMCH-V)
Pavlova, Ewa (UMCH-V) RID
Proks, Vladimír (UMCH-V) RID, ORCIDArticle number 110347 Source Title European Polymer Journal. - : Elsevier - ISSN 0014-3057
Roč. 148, 5 April (2021)Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords polyaspartamide ; zwitterionic polypeptide ; polysuccinimide Subject RIV EI - Biotechnology ; Bionics OECD category Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials R&D Projects GA18-03224S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000639291300002 EID SCOPUS 85101500212 DOI 10.1016/j.eurpolymj.2021.110347 Annotation The ability of polysuccinimide (PSI) to open the succinimide ring by nucleophilic reagents leads to the formation of various polyaspartamides under mild conditions. In the current work, amino acids, such as Nα-Boc-L-lysine, leading to the formation of exclusively α-substituted L-lysine polypeptides and L-lysine methyl ester were used as the ring-opening reagents for PSI. The formed materials possess both positively and negatively charged groups on the same repeat unit simultaneously serving as zwitterionic moieties. The chemical structure and component composition were confirmed by 1H NMR and UV/vis spectroscopies. Zwitterionic properties of the synthesized polymers were investigated by zeta potential measurements. The obtained zwitterionic polyaspartamides exhibited anti-protein adsorption properties and the ability to create hydrophilic surfaces. The zwitterionic polyaspartamide nanogels obtained by horseradish peroxidase-mediated crosslinking in inverse miniemulsions and applying different preparation strategies were analysed by dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) analysis. The results indicated the good morphology and architecture of the nanogels. These peptide-based zwitterionic nanogels, due to their good biocompatibility and anti-protein adsorption ability, are promising materials for biomedical applications. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S0014305721000811?via%3Dihub
Number of the records: 1