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A review on the latest advances in extraction and analysis of artemisinin
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SYSNO ASEP 0540409 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A review on the latest advances in extraction and analysis of artemisinin Author(s) Nahar, Lutfun (UEB-Q) ORCID
Guo, M. (CN)
Sarker, S. D. (GB)Number of authors 3 Source Title Phytochemical Analysis. - : Wiley - ISSN 0958-0344
Roč. 31, č. 1 (2020), s. 5-14Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords analysis ; Artemisia annua ; artemisinin ; extraction ; hplc ; lc-ms ; Nobel prize ; supercritical fluid extraction ; Tu Youyou ; ultrasound-assisted extraction Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry Method of publishing Open access Institutional support UEB-Q - RVO:61389030 UT WOS 000612360400001 EID SCOPUS 85070094493 DOI 10.1002/pca.2873 Annotation Introduction: Artemisinin (1), a well-known natural antimalarial drug, is a sesquiterpene lactone that contains a unique peroxide bridge. Since its discovery, the amount of research into the analysis of artemisinin has increased considerably, and it has been further intensified since the Noble Prize win by Tu Youyou in the year 2015 for the discovery of artemisinin. Objective: To review literature on the extraction and analysis of artemisinin, published during 2017–present, and to present an appraisal of those methods. Methodology: Extensive literature search was carried out which involved, but not limited to, the use of, various databases, like Web of Knowledge, PubMed and Google Scholar, and relevant published materials including published books. The keywords used, in various combinations, with artemisinin being present in all combinations, in the search were artemisinin, Artemisia annua, analysis, extraction, quantitative, qualitative and quality control. Results: During the period covered in this review, several methods of analysis of artemisinin have been reported, the most of which were liquid chromatography (LC)-based methods. However, the use of new methods like near-infrared analysis, fluorometirc analysis and molecular imprinting, and a significant increase in the use of computational tools have been observed. Mainly several methods involving supercritical fluid extraction and ultrasound-assisted extraction of artemisinin have dominated the extraction area. Conclusions: Newer analytical tools, as well as improved protocols for the known analytical tools, for qualitative and quantitative determination of artemisinin (1), have been made available by various researchers during the period covered by this review. Supercritical fluid extraction and ultrasound-assisted extraction are still the methods of choice for extraction of artemisinin. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2021 Electronic address http://doi.org/10.1002/pca.2873
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