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Postnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system
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SYSNO ASEP 0539953 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Postnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system Author(s) Svobodová Buriánová, Jana (UEM-P)
Syka, Josef (UEM-P) RIDSource Title Brain Structure and Function. - : Springer - ISSN 1863-2653
Roč. 225, č. 7 (2020), s. 1979-1995Number of pages 17 s. Language eng - English Country DE - Germany Keywords enriched environment ; critical period ; dendrites Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects EF15_003/0000419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LTAIN19201 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UEM-P - RVO:68378041 UT WOS 000543316000001 EID SCOPUS 85087059597 DOI 10.1007/s00429-020-02104-8 Annotation The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat pups. AEE consisted of a spectrally and temporally modulated sound of moderate intensity, reinforced by a behavioral paradigm. At the age of 3-6 months, a Golgi-Cox staining was used to evaluate the morphology of neurons in the inferior colliculus (IC), the medial geniculate body (MGB), and the auditory cortex (AC). Compared to controls, rats exposed to AEE showed an increased mean dendritic length and volume and the soma surface in the external cortex and the central nucleus of the IC. The spine density increased in both the ventral and dorsal divisions of the MGB. In the AC, the total length and volume of the basal dendritic segments of pyramidal neurons and the number and density of spines on these dendrites increased significantly. No differences were found on apical dendrites. We also found an elevated number of spines and spine density in non-pyramidal neurons. These results show that exposure to AEE during the critical developmental period can induce permanent changes in the structure of neurons in the central auditory system. These changes represent morphological correlates of the functional plasticity, such as an improvement in frequency tuning and synchronization with temporal parameters of acoustical stimuli. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2021 Electronic address https://link.springer.com/article/10.1007%2Fs00429-020-02104-8
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