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Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

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    SYSNO ASEP0539306
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleChromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients
    Author(s) Vodenková, Soňa (UEM-P)
    Kroupa, Michal (UEM-P)
    Polívková, Z. (CZ)
    Musak, L. (SK)
    Ambruš, M. (CZ)
    Schneiderová, M. (CZ)
    Kozevnikovová, R. (CZ)
    Vodičková, Ludmila (UEM-P) RID
    Rachakonda, S. (DE)
    Hemminki, K. (DE)
    Kumar, R. (DE)
    Vodička, Pavel (UEM-P) RID
    Source TitleOncology Reports - ISSN 1021-335X
    Roč. 44, č. 5 (2020), s. 2219-2230
    Number of pages12 s.
    Languageeng - English
    CountryGR - Greece
    Keywordsstructural chromosomal aberrations ; telomere length ; peripheral blood lymphocytes
    Subject RIVFD - Oncology ; Hematology
    OECD categoryOncology
    R&D ProjectsGA18-09709S GA ČR - Czech Science Foundation (CSF)
    NV15-27580A GA MZd - Ministry of Health (MZ)
    Method of publishingLimited access
    Institutional supportUEM-P - RVO:68378041
    UT WOS000582501500039
    EID SCOPUS85092093899
    DOI10.3892/or.2020.7774
    AnnotationAccumulation of non-specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer-free control individuals were investigated. These results were then correlated with clinicopathological factors and follow-up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid-type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.
    WorkplaceInstitute of Experimental Medicine
    ContactLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Year of Publishing2021
    Electronic addresshttps://www.spandidos-publications.com/10.3892/or.2020.7774
Number of the records: 1