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Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients
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SYSNO ASEP 0539306 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients Author(s) Vodenková, Soňa (UEM-P) ORCID, RID
Kroupa, Michal (UEM-P)
Polívková, Z. (CZ)
Musak, L. (SK)
Ambruš, M. (CZ)
Schneiderová, M. (CZ)
Kozevnikovová, R. (CZ)
Vodičková, Ludmila (UEM-P) RID
Rachakonda, S. (DE)
Hemminki, K. (DE)
Kumar, R. (DE)
Vodička, Pavel (UEM-P) RIDSource Title Oncology Reports - ISSN 1021-335X
Roč. 44, č. 5 (2020), s. 2219-2230Number of pages 12 s. Language eng - English Country GR - Greece Keywords structural chromosomal aberrations ; telomere length ; peripheral blood lymphocytes Subject RIV FD - Oncology ; Hematology OECD category Oncology R&D Projects GA18-09709S GA ČR - Czech Science Foundation (CSF) NV15-27580A GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support UEM-P - RVO:68378041 UT WOS 000582501500039 EID SCOPUS 85092093899 DOI 10.3892/or.2020.7774 Annotation Accumulation of non-specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer-free control individuals were investigated. These results were then correlated with clinicopathological factors and follow-up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid-type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2021 Electronic address https://www.spandidos-publications.com/10.3892/or.2020.7774
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