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Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View
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SYSNO ASEP 0538195 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View Author(s) Eftimov, P. (BG)
Olžyńska, Agnieszka (UFCH-W) RID
Melcrová, Adéla (UFCH-W)
Georgiev, G. A. (PT)
Daull, P. (FR)
Garrigue, J.-S. (FR)
Cwiklik, Lukasz (UFCH-W) RID, ORCIDArticle number 9490 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 21, č. 24 (2020)Number of pages 15 s. Language eng - English Country CH - Switzerland Keywords dry eye disease ; cationic emulsion ; surface-chemistry ; benzalkonium chloride ; vicious circle ; efficacy ; meibum ; pathophysiology ; moderate ; tension ; tear film Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GA18-26751S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 000602786100001 EID SCOPUS 85097758857 DOI 10.3390/ijms21249490 Annotation The tear film at the ocular surface is covered by a thin layer of lipids. This oily phase stabilizes the film by decreasing its surface tension and improving its viscoelastic properties. Clinically, destabilization and rupture of the tear film are related to dry eye disease and are accompanied by changes in the quality and quantity of tear film lipids. In dry eye, eye drops containing oil-in-water emulsions are used for the supplementation of lipids and surface-active components to the tear film. We explore in detail the biophysical aspects of interactions of specific surface-active compounds, cetalkonium chloride and poloxamer 188, which are present in oil-in-water emulsions, with tear lipids. The aim is to better understand the macroscopically observed eye drops-tear film interactions by rationalizing them at the molecular level. To this end, we employ a multi-scale approach combining experiments on human meibomian lipid extracts, measurements using synthetic lipid films, and in silico molecular dynamics simulations. By combining these methods, we demonstrate that the studied compounds specifically interact with the tear lipid film enhancing its structure, surfactant properties, and elasticity. The observed effects are cooperative and can be further modulated by material packing at the tear-air interface. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0316017
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