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Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View

SYSNO ASEP	0538195
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View
Author(s)	Eftimov, P. (BG) Olžyńska, Agnieszka (UFCH-W)_RID Melcrová, Adéla (UFCH-W) Georgiev, G. A. (PT) Daull, P. (FR) Garrigue, J.-S. (FR) Cwiklik, Lukasz (UFCH-W)_{RID, ORCID}
Article number	9490
Source Title	International Journal of Molecular Sciences. - : MDPI Roč. 21, č. 24 (2020)
Number of pages	15 s.
Language	eng - English
Country	CH - Switzerland
Keywords	dry eye disease ; cationic emulsion ; surface-chemistry ; benzalkonium chloride ; vicious circle ; efficacy ; meibum ; pathophysiology ; moderate ; tension ; tear film
Subject RIV	CF - Physical ; Theoretical Chemistry
OECD category	Physical chemistry
R&D Projects	GA18-26751S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	UFCH-W - RVO:61388955
UT WOS	000602786100001
EID SCOPUS	85097758857
DOI	10.3390/ijms21249490
Annotation	The tear film at the ocular surface is covered by a thin layer of lipids. This oily phase stabilizes the film by decreasing its surface tension and improving its viscoelastic properties. Clinically, destabilization and rupture of the tear film are related to dry eye disease and are accompanied by changes in the quality and quantity of tear film lipids. In dry eye, eye drops containing oil-in-water emulsions are used for the supplementation of lipids and surface-active components to the tear film. We explore in detail the biophysical aspects of interactions of specific surface-active compounds, cetalkonium chloride and poloxamer 188, which are present in oil-in-water emulsions, with tear lipids. The aim is to better understand the macroscopically observed eye drops-tear film interactions by rationalizing them at the molecular level. To this end, we employ a multi-scale approach combining experiments on human meibomian lipid extracts, measurements using synthetic lipid films, and in silico molecular dynamics simulations. By combining these methods, we demonstrate that the studied compounds specifically interact with the tear lipid film enhancing its structure, surfactant properties, and elasticity. The observed effects are cooperative and can be further modulated by material packing at the tear-air interface.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2021
Electronic address	http://hdl.handle.net/11104/0316017

Number of the records: 1