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Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth
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SYSNO ASEP 0537924 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth Author(s) Kasálková-Slepičková, N. (CZ)
Slepička, P. (CZ)
Ivanovská, B. (CZ)
Trávníčková, Martina (FGU-C) RID, ORCID, SAI
Malinský, Petr (UJF-V) RID, ORCID, SAI
Macková, Anna (UJF-V) RID, ORCID, SAI
Bačáková, Lucie (FGU-C) RID, ORCID
Švorčík, V. (CZ)Article number 1083 Source Title Coatings. - : MDPI - ISSN 2079-6412
Roč. 10, č. 11 (2020)Number of pages 20 s. Language eng - English Country CH - Switzerland Keywords cytocompatibility ; nanoparticle doping ; plasma treatment ; polymer ; PVA ; surface characterization ; tissue engineering Subject RIV EI - Biotechnology ; Bionics OECD category Biomaterials (as related to medical implants, devices, sensors) Subject RIV - cooperation Nuclear Physics Institute - Nuclear, Atomic and Molecular Physics, Colliders R&D Projects GA19-02482S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support FGU-C - RVO:67985823 ; UJF-V - RVO:61389005 UT WOS 000592729900001 DOI https://doi.org/10.3390/coatings10111083 Annotation Hydrogels, and not only natural polysaccharide hydrogels, are substances capable of absorbing large amounts of water and physiological fluids. In this study, we set out to optimize the process for preparing polyvinyl alcohol (PVA) hydrogels. Subsequently, we doped PVA foils with cellulose powder, with poly(ethylene glycol) (PEG) or with gold nanoparticles in PEG colloid solutions (Au). The foils were then modified in a plasma discharge to improve their biocompatibility. The properties of PVA foils were studied by various analytical methods. The use of a suitable dopant can significantly affect the surface wettability, the roughness, the morphology and the mechanical properties of the material. Plasma treatment of PVA leads to ultraviolet light-induced crosslinking and decreasing water absorption. At the same time, this treatment significantly improves the cytocompatibility of the polymer, which is manifested by enhanced growth of human adipose-derived stem cells. This positive effect on the cell behavior was most pronounced on PVA foils doped with PEG or with Au. This modification of PVA therefore seems to be most suitable for the use of this polymer as a cell carrier for tissue engineering, wound healing and other regenerative applications. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://www.mdpi.com/2079-6412/10/11/1083
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