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Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth

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    SYSNO ASEP0537924
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitlePlasma-Activated Polyvinyl Alcohol Foils for Cell Growth
    Author(s) Kasálková-Slepičková, N. (CZ)
    Slepička, P. (CZ)
    Ivanovská, B. (CZ)
    Trávníčková, Martina (FGU-C) RID, ORCID
    Malinský, Petr (UJF-V) RID, ORCID
    Macková, Anna (UJF-V) RID, ORCID
    Bačáková, Lucie (FGU-C) RID, ORCID
    Švorčík, V. (CZ)
    Article number1083
    Source TitleCoatings - ISSN 2079-6412
    Roč. 10, č. 11 (2020)
    Number of pages20 s.
    Languageeng - English
    CountryCH - Switzerland
    Keywordscytocompatibility ; nanoparticle doping ; plasma treatment ; polymer ; PVA ; surface characterization ; tissue engineering
    Subject RIVEI - Biotechnology ; Bionics
    OBOR OECDBiomaterials (as related to medical implants, devices, sensors)
    Subject RIV - cooperationNuclear Physics Institute - Nuclear, Atomic and Molecular Physics, Colliders
    R&D ProjectsGA19-02482S GA ČR - Czech Science Foundation (CSF)
    Způsob publikováníOpen access
    Institutional supportFGU-C - RVO:67985823 ; UJF-V - RVO:61389005
    UT WOS000592729900001
    AnnotationHydrogels, and not only natural polysaccharide hydrogels, are substances capable of absorbing large amounts of water and physiological fluids. In this study, we set out to optimize the process for preparing polyvinyl alcohol (PVA) hydrogels. Subsequently, we doped PVA foils with cellulose powder, with poly(ethylene glycol) (PEG) or with gold nanoparticles in PEG colloid solutions (Au). The foils were then modified in a plasma discharge to improve their biocompatibility. The properties of PVA foils were studied by various analytical methods. The use of a suitable dopant can significantly affect the surface wettability, the roughness, the morphology and the mechanical properties of the material. Plasma treatment of PVA leads to ultraviolet light-induced crosslinking and decreasing water absorption. At the same time, this treatment significantly improves the cytocompatibility of the polymer, which is manifested by enhanced growth of human adipose-derived stem cells. This positive effect on the cell behavior was most pronounced on PVA foils doped with PEG or with Au. This modification of PVA therefore seems to be most suitable for the use of this polymer as a cell carrier for tissue engineering, wound healing and other regenerative applications.
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová,, Tel.: 241 062 400
    Year of Publishing2021
    Electronic address
Number of the records: 1