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Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications
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SYSNO ASEP 0537561 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications Author(s) Frtús, Adam (FZU-D) ORCID
Smolková, Barbora (FZU-D) ORCID
Uzhytchak, Mariia (FZU-D) ORCID
Lunova, Mariia (FZU-D) ORCID
Jirsa, M. (CZ)
Kubinová, Šárka (FZU-D) RID, ORCID
Dejneka, Alexandr (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCIDNumber of authors 8 Source Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 328, Dec (2020), s. 59-77Number of pages 19 s. Language eng - English Country NL - Netherlands Keywords iron oxide nanoparticles ; endocytosis ; magnetic resonance imaging ; cytotoxicity ; lysosomes ; apoptosis ; autophagy ; cancer Subject RIV BO - Biophysics OECD category Biophysics R&D Projects LTC19040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 000600791600005 EID SCOPUS 85089899628 DOI 10.1016/j.jconrel.2020.08.036 Annotation Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2021 Electronic address https://doi.org/10.1016/j.jconrel.2020.08.036
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