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The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes
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SYSNO ASEP 0537343 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes Author(s) Číž, Milan (BFU-R) RID, ORCID
Dvořáková, Adéla (BFU-R)
Skočková, Veronika (BFU-R)
Kubala, Lukáš (BFU-R) RID, ORCIDNumber of authors 4 Article number 691 Source Title Antioxidants. - : MDPI
Roč. 9, č. 8 (2020)Number of pages 19 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords proinflammatory cytokine production ; immune function ; dna methylation ; histone h3 ; in-vitro ; polyphenols ; resveratrol Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 000567166800001 EID SCOPUS 85090629678 DOI 10.3390/antiox9080691 Annotation A better understanding of the interactions between dietary phenolic compounds and the epigenetics of inflammation may impact pathological conditions and their treatment. Phenolic compounds are well-known for their antioxidant, anti-inflammatory, anti-angiogenic, and anti-cancer properties, with potential benefits in the treatment of various human diseases. Emerging studies bring evidence that nutrition may play an essential role in immune system modulation also by altering gene expression. This review discusses epigenetic mechanisms such as DNA methylation, post-translational histone modification, and non-coding microRNA activity that regulate the gene expression of molecules involved in inflammatory processes. Special attention is paid to the molecular basis of NF-kappa B modulation by dietary phenolic compounds. The regulation of histone acetyltransferase and histone deacetylase activity, which all influence NF-kappa B signaling, seems to be a crucial mechanism of the epigenetic control of inflammation by phenolic compounds. Moreover, chronic inflammatory processes are reported to be closely connected to the major stages of carcinogenesis and other non-communicable diseases. Therefore, dietary phenolic compounds-targeted epigenetics is becoming an attractive approach for disease prevention and intervention. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2021 Electronic address https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=AdvancedSearch&qid=6&SID=F1xluL7bYBwwklPNBfn&page=1&doc=1
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