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Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism
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SYSNO ASEP 0536721 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism Author(s) Ahuja, V. (IN)
Macho, Markéta (MBU-M) ORCID
Ewe, Daniela (MBU-M) ORCID
Singh, M. (IN)
Saha, Subhasish (MBU-M) ORCID
Saurav, Kumar (MBU-M) ORCIDNumber of authors 6 Article number 1592 Source Title Foods. - : MDPI
Roč. 9, č. 11 (2020)Number of pages 24 s. Language eng - English Country CH - Switzerland Keywords xylitol ; nutritive sweetener ; anti-cancer ; anti-inflammatory ; respiratory tract infection ; cardiovascular diseases Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects EF18_070/0010493 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GJ19-17868Y GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000593265700001 DOI 10.3390/foods9111592 Annotation Xylitol is a white crystalline, amorphous sugar alcohol and low-calorie sweetener. Xylitol prevents demineralization of teeth and bones, otitis media infection, respiratory tract infections, inflammation and cancer progression. NADPH generated in xylitol metabolism aid in the treatment of glucose-6-phosphate deficiency-associated hemolytic anemia. Moreover, it has a negligible effect on blood glucose and plasma insulin levels due to its unique metabolism. Its diverse applications in pharmaceuticals, cosmetics, food and polymer industries fueled its market growth and made it one of the top 12 bio-products. Recently, xylitol has also been used as a drug carrier due to its high permeability and non-toxic nature. However, it become a challenge to fulfil the rapidly increasing market demand of xylitol. Xylitol is present in fruit and vegetables, but at very low concentrations, which is not adequate to satisfy the consumer demand. With the passage of time, other methods including chemical catalysis, microbial and enzymatic biotransformation, have also been developed for its large-scale production. Nevertheless, large scale production still suffers from high cost of production. In this review, we summarize some alternative approaches and recent advancements that significantly improve the yield and lower the cost of production. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2021 Electronic address https://www.mdpi.com/2304-8158/9/11/1592
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