Number of the records: 1
Synthesis, characterisation and supercritical fluid chromatography enantioseparation of new liquid crystalline materials
- 1.
SYSNO ASEP 0536056 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis, characterisation and supercritical fluid chromatography enantioseparation of new liquid crystalline materials Author(s) Urbańska, M. (PL)
Vaňkátová, Petra (FZU-D) ORCID, RID
Kubíčková, A. (CZ)
Kalíková, K. (CZ)Number of authors 4 Source Title Liquid Crystals. - : Taylor & Francis - ISSN 0267-8292
Roč. 47, č. 12 (2020), s. 1832-1843Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords liquid crystal ; synthesis ; racemic mixtures ; enantioseparation ; supercritical fluid chromatography Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 000527426800001 EID SCOPUS 85082427490 DOI 10.1080/02678292.2020.1733684 Annotation Enantiomeric excess (EE) highly affects the mesomorphic properties of mesogens containing centre of chirality. Thus, there is need of methods for evaluation of the EE of newly synthesised compounds as it should be considered when discussing the mesomorphic properties. We report synthesis and characterisation of ten new racemic mixtures based on (R,S)-3-octanol, which were used to develop an enantioseparation method that can be used for the assessment of the EE of chiral liquid crystals and their mixtures. The mesomorphic properties of novel materials were measured. Supercritical fluid chromatography with polysaccharide-based chiral stationary phases was used to develop reliable method for enantioseparation of the materials. A complete separation of (S) and (R) enantiomers with resolution values higher than 2.0 was obtained for all materials using simple mobile phase. The enantiomer elution order was assessed using pure (S) enantiomers of all materials. For all materials (R) enantiomer elutes first which is advantageous for use as optical purity control of newly synthesised (S) enantiomers. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2021 Electronic address https://doi.org/10.1080/02678292.2020.1733684
Number of the records: 1