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Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19
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SYSNO ASEP 0535751 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19 Author(s) Brábek, J. (CZ)
Jakůbek, M. (CZ)
Vellieux, F. (CZ)
Novotný, Jiří (UMG-J) ORCID
Kolář, Michal (UMG-J) RID, ORCID
Lacina, L. (CZ)
Szabo, P. (CZ)
Strnadová, K. (CZ)
Rösel, D. (CZ)
Dvainkova, B. (CZ)
Smetana, K. (CZ)Number of authors 11 Article number 7937 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 21, č. 21 (2020)Number of pages 25 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords tumour microenvironment ; cancer ecosystem ; ageing ; covid-19 ; il-6 ; cytokine storm ; cytokine ; cancer-associated fibroblasts Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000588928900001 DOI 10.3390/ijms21217937 Annotation Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2021 Electronic address https://www.mdpi.com/1422-0067/21/21/7937
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