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Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

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    SYSNO ASEP0535751
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleInterleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19
    Author(s) Brábek, J. (CZ)
    Jakůbek, M. (CZ)
    Vellieux, F. (CZ)
    Novotný, Jiří (UMG-J)
    Kolář, Michal (UMG-J) RID
    Lacina, L. (CZ)
    Szabo, P. (CZ)
    Strnadová, K. (CZ)
    Rösel, D. (CZ)
    Dvainkova, B. (CZ)
    Smetana, K. (CZ)
    Number of authors11
    Article number7937
    Source TitleInternational Journal of Molecular Sciences. - : MDPI
    Roč. 21, č. 21 (2020)
    Number of pages25 s.
    Publication formOnline - E
    Languageeng - English
    CountryCH - Switzerland
    Keywordstumour microenvironment ; cancer ecosystem ; ageing ; covid-19 ; il-6 ; cytokine storm ; cytokine ; cancer-associated fibroblasts
    Subject RIVEB - Genetics ; Molecular Biology
    OECD categoryBiochemistry and molecular biology
    R&D ProjectsED1.1.00/02.0109 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    Method of publishingOpen access
    Institutional supportUMG-J - RVO:68378050
    UT WOS000588928900001
    DOI10.3390/ijms21217937
    AnnotationInterleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections.
    WorkplaceInstitute of Molecular Genetics
    ContactGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Year of Publishing2021
    Electronic addresshttps://www.mdpi.com/1422-0067/21/21/7937
Number of the records: 1