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Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

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    SYSNO ASEP0535546
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleHighly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes
    Author(s) Kostiv, Uliana (UMCH-V) RID
    Kučka, Jan (UMCH-V) RID, ORCID
    Lobaz, Volodymyr (UMCH-V) RID, ORCID
    Kotov, Nikolay (UMCH-V) RID, ORCID
    Janoušková, Olga (UMCH-V) RID, SAI, ORCID
    Šlouf, Miroslav (UMCH-V) RID, ORCID
    Krajnik, B. (PL)
    Podhorodecki, A. (PL)
    Francová, P. (CZ)
    Šefc, L. (CZ)
    Jirák, D. (CZ)
    Horák, Daniel (UMCH-V) RID, ORCID
    Article number20016
    Source TitleScientific Reports. - : Nature Publishing Group - ISSN 2045-2322
    Roč. 10, č. 1 (2020), s. 1-14
    Number of pages14 s.
    Languageeng - English
    CountryGB - United Kingdom
    Keywordsupconversion ; magnetic ; PEG-neridronate
    Subject RIVCD - Macromolecular Chemistry
    OECD categoryPolymer science
    R&D ProjectsGA19-00676S GA ČR - Czech Science Foundation (CSF)
    GA18-07983S GA ČR - Czech Science Foundation (CSF)
    TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
    LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    8JPL19006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Research InfrastructureCzech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
    Method of publishingOpen access
    Institutional supportUMCH-V - RVO:61389013
    UT WOS000595719100001
    EID SCOPUS85096206151
    DOI10.1038/s41598-020-77112-z
    AnnotationAll-in-one multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained on phantoms with different particle concentrations and during pilot long-time in vivo observations of a mouse model. The biological and physicochemical properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles make them promising as a trimodal optical/MRI/SPECT bioimaging and theranostic nanoprobe for experimental medicine.
    WorkplaceInstitute of Macromolecular Chemistry
    ContactEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Year of Publishing2021
    Electronic addresshttps://www.nature.com/articles/s41598-020-77112-z
Number of the records: 1  

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