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Increased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot

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    SYSNO ASEP0535240
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleIncreased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot
    Author(s) Novotný, Tomáš (FGU-C) ORCID, RID
    Eckhardt, Adam (FGU-C) RID, ORCID
    Knitlová, Jarmila (FGU-C) RID, ORCID
    Doubková, Martina (FGU-C) ORCID, RID
    Ošťádal, M. (CZ)
    Uhlík, J. (CZ)
    Musílková, Jana (FGU-C) RID, ORCID
    Source TitleJournal of Pediatric Orthopaedics. - : Lippincott Williams & Wilkins - ISSN 0271-6798
    Roč. 40, č. 10 (2020), s. 592-596
    Number of pages5 s.
    Languageeng - English
    CountryUS - United States
    Keywordsclubfoot ; microvessel density ; arteriole density ; proangiogenic factors ; gene expression ; immunohistochemistry
    Subject RIVFI - Traumatology, Orthopedics
    OECD categoryOrthopaedics
    R&D ProjectsNV17-31564A GA MZd - Ministry of Health (MZ)
    Method of publishingLimited access
    Institutional supportFGU-C - RVO:67985823
    UT WOS000578094000009
    EID SCOPUS85091449211
    AnnotationClubfoot deformity (pes equinovarus) is one of the most common birth defects, and its etiology is still unknown. Initial clubfoot treatment is based on the Ponseti method throughout most of the world. Despite the effectiveness of this therapy, clubfoot may relapse. Recent studies confirm the theory of active fibrotic remodeling processes in the extracellular matrix of the affected tissue. The aim of this study was to clarify whether relapses in clubfoot therapy are associated with altered angiogenesis and to suggest possible regulatory pathways of this pathologic process.
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová,, Tel.: 241 062 400
    Year of Publishing2021
    Electronic address
Number of the records: 1  

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