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Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer

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    SYSNO ASEP0534443
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleInternal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer
    Author(s) Babuka, David (UMCH-V)
    Kolouchová, Kristýna (UMCH-V) ORCID, RID
    Groborz, Ondřej (UMCH-V) ORCID, RID
    Tosner, Z. (CZ)
    Zhigunov, Alexander (UMCH-V) RID, ORCID
    Štěpánek, Petr (UMCH-V) RID, ORCID
    Hrubý, Martin (UMCH-V) RID, ORCID
    Article number2231
    Source TitleNanomaterials
    Roč. 10, č. 11 (2020), s. 1-17
    Number of pages17 s.
    Languageeng - English
    CountryCH - Switzerland
    Keywordsfluorine-19 ; magnetic resonance imaging ; self-assembly
    Subject RIVCD - Macromolecular Chemistry
    OBOR OECDPolymer science
    R&D ProjectsLTC19032 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    GA19-01602S GA ČR - Czech Science Foundation (CSF)
    GA18-07983S GA ČR - Czech Science Foundation (CSF)
    Způsob publikováníOpen access
    Institutional supportUMCH-V - RVO:61389013
    UT WOS000594374500001
    EID SCOPUS85095877392
    DOI10.3390/nano10112231
    AnnotationFluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei.
    WorkplaceInstitute of Macromolecular Chemistry
    ContactEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Year of Publishing2021
    Electronic addresshttps://www.mdpi.com/2079-4991/10/11/2231
Number of the records: 1