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Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer
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SYSNO ASEP 0534443 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer Author(s) Babuka, David (UMCH-V)
Kolouchová, Kristýna (UMCH-V) ORCID, RID
Groborz, Ondřej (UMCH-V) ORCID, RID
Tosner, Z. (CZ)
Zhigunov, Alexander (UMCH-V) RID, ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDArticle number 2231 Source Title Nanomaterials. - : MDPI
Roč. 10, č. 11 (2020), s. 1-17Number of pages 17 s. Language eng - English Country CH - Switzerland Keywords fluorine-19 ; magnetic resonance imaging ; self-assembly Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LTC19032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-01602S GA ČR - Czech Science Foundation (CSF) GA18-07983S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000594374500001 EID SCOPUS 85095877392 DOI 10.3390/nano10112231 Annotation Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://www.mdpi.com/2079-4991/10/11/2231
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